UTY demethylates the repression-associated modified histone H3K27me3 (Walport et al., 2014), whereas KDM5D demethylates the activation-associated modified histone H3K4me3 (Iwase et al., 2007), a prominent target for anti-nuclear autoimmunity in female (NZW×B6.Lbric)F1 mice. Here, KDM5D is linked to Autoimmunity.