This alteration in neutrophil nuclear morphology in SLE resembles the Pelger–Huet anomaly (Fig. 1A), an autosomal dominant genetic disorder that results in nuclear alterations due to impaired expression of the nuclear membrane protein LBR (Hoffmann et al., 2002; Shultz et al., 2003; Olins et al., 2008). Here, LBR is linked to systemic lupus erythematosus.