MYB and systemic lupus erythematosus: In humans, EMHT2/G9a is in the well-established lupus-susceptibility interval embedded in the human leukocyte antigen (HLA) locus at 6p21.31 (Brown et al., 2001), and high-resolution fine-mapping of the HLA interval identified a polymorphic variant within a Myb-family binding site in the EMHT2/G9a enhancer as a prominent lupus risk allele (Kim et al., 2012; Armstrong et al., 2014).