The human CALR gene is encoded on chromosome 19, which is prone to genomic alterations in abnormal neutrophils isolated from SLE patients (Singh et al., 2014), and somatic insertion/deletion mutations in exon 9 of calreticulin have been identified in myeloproliferative neoplasms with non-mutated JAK2 kinase (Klampfl et al., 2013; Nangalia et al., 2013; Rumi et al., 2014). This evidence concerns the gene CALR and systemic lupus erythematosus.