Although rs558702 is in the second intron of the complement protein 2 (C2) gene, it is positioned less than 5 kb upstream of the transcriptional start site for EMHT2/G9a, providing an alternative mechanism for HLA-associated lupus susceptibility through disruption of EMHT2/G9a regulation and epigenetic alterations that affect the A-type lamina. This evidence concerns the gene C2 and systemic lupus erythematosus.