In contrast, FOXC1 and PITX2, which are mutated in both Axenfeld–Rieger syndrome and Iridogoniodysgenesis, are transcription factors that function in the NCC-derived POM to regulate development of the anterior segment (Gage et al., 1999, 2005, 2014; Kume et al., 1998; Seo et al., 2012). The gene discussed is PITX2; the disease is iridogoniodysgenesis.