EGCG interacts with target proteins in the breast cancer cells, such as ERα, Zap-70, PI3K, G3BP1, IGF-1R, vimentin, Bcl-2, Bcl-xL, GRP78, and Fyn via hydrogen bonding, which plays a role in the inhibition of breast cancer. This evidence concerns the gene ZAP70 and breast carcinoma.