Oligonol—a catechin-rich preparation—triggered apoptosis in estrogen-responsive MCF-7 and estrogen-unresponsive MDA-MB-231 breast cancer cells through the modulation of pro-apoptotic Bcl-2 family proteins and MEK/ERK signaling pathway [66]; (4) Inhibiting fatty acid synthase (FAS). The gene discussed is FAS; the disease is breast carcinoma.