AGRN and glioblastoma: In addition, the activity of matrixmetalloproteinases MMP2, 9, and 3 play a pivotal role in this scenario: if agrin is cleaved by MMP3 [17]—such as in glioblastoma—no typical OAPs are found and if MMP2 and 9 cleave dystroglycan [18]—such as in glioblastoma—no OAPs are formed as well.