Figure 1 shows the freeze fracture replicas of the examined astrocytoma tissues: low-grade astrocytomas (WHO grade II; Figure 1A) revealed membranes with OAPs. The astrocytoma WHO grade III (Figure 1B) showed a few OAPs. IDH1 (isocitrate dehydrogenase 1 (NADP(+))-negative (non-mutated) glioblastomas (Figure 1C) formed only few and sometimes misshapen OAPs or membranes lacking any OAPs. This evidence concerns the gene IDH1 and astrocytoma (excluding glioblastoma).