In this study we found that seven genes involved in T2D (CD36, CD38, FOXP1, SELL, PPARA, PPARG, AGT) and two genes involved in anorexia (AKAP6, NTNG1) were differently expressed in the small intestinal tissue of celiac patients compared with control patients, suggesting common genetic pathways leading to the disease among these phenotypically different chronic disorders. This evidence concerns the gene CD38 and type 2 diabetes mellitus.