The presence of the VEGF165 transgene alone (Kimba) and the combination of transgene and hyperglycaemia in Akimba mice led to significant fold-change increases in Edn2 mRNA (Kimba: 5.3; Akimba: 7.9, p<0.05, Fig 1A) and Ednrb (Kimba: 6.0; Akimba: 8.8, p<0.01, Fig 1B) expression even in young mice, although the difference between young Kimba and Akimba mice was not significant. Here, EDN2 is linked to Hyperglycemia.