ZMPSTE24 and mandibuloacral dysplasia: MAD with type A lipodystrophy (MADA) is induced by the homozygous R527H LMNA mutation, which leads to accumulation of prelamin A and changes in nuclear architecture (Novelli et al., 2002), whereas MAD with type B lipodystrophy (MADB) is caused by compound heterozygous mutations in ZMPSTE24 (Agarwal et al., 2003).