Our study findings that the genoprevalence of vaccine HPV-16/18 strains were not significantly lower among subgroups of vaccinated girls such as those with other STIs (HIV/syphilis), CD4 count <500 cells/mm3, abnormal BMI, multiple lifetime sexual partners and non-condom use when compared to their non-vaccinated counterparts is unique. The gene discussed is CD4; the disease is syphilis.