SGK3 and neoplasm: However, it is not clear whether the reactivation was mediated through SGK3 phosphorylating TSC2 at Akt sites (Thr1462), since the tumour samples obtained from monotreated (MK‐2206) or combination (MK‐2206 and 14h) mice showed similar level of TSC2 phosphorylation (Fig 8H).