Although the focus has been on the role that Akt isoforms play in mediating proliferation responses that are controlled by Class I PI3Ks, increasing evidence is accumulating that isoforms of serum and glucocorticoid regulated kinases (SGK) which share ~50% identity within their catalytic domains to Akt, also control proliferation and survival responses in cancer cells (Vasudevan et al, 2009; Bruhn et al, 2010, 2013; Pearce et al, 2010; Bago et al, 2014; Gasser et al, 2014). This evidence concerns the gene AKT1 and cancer.