It would be important to investigate the molecular mechanism by which prolonged inhibition of Akt or Class I PI3K leads to kinome‐wide changes in mRNA expression levels, and in particular SGK3 mRNA and whether the upregulation of SGK3 protein and activity is limited to ER/AR cell backgrounds/tumours, or applicable to broader group of cancer cells. This evidence concerns the gene AKT1 and neoplasm.