In the past 5 years, IRF5 has become a molecule of high interest given its important role(s) in regulating inflammation and immunity7, 8, 10, 19, 22, 24, as well as recent new findings that implicate IRF5 in the regulation of neuropathic pain, obesity, myocardial infarction, allograft rejection, atherosclerosis, and metabolic dysfunction25, 26, 27, 28, 42. Here, IRF5 is linked to atherosclerosis.