Furthermore, it is well described in the TSPO imaging literature [49–51] that models or clinical cases in which a strong neuroinflammation (such as in stroke) are much easier to model consistently, whereas in the case of low or subtle neuroinflammation levels as observed in neurodegenerative diseases, the modelling is far more challenging, leading to discrepancies between studies. This evidence concerns the gene TSPO and neurodegenerative disease.