ALS-related mutations in a range of genes including TDP-43, FUS, hnRNPA1, profilin-1, angiogenin and C9ORF72 were found to result in abnormalities in stress granule dynamics [2, 4, 7, 13, 20, 22, 33, 38, 59, 61, 63, 69]. This evidence concerns the gene HNRNPA1 and amyotrophic lateral sclerosis.