We have demonstrated here that cytoplasmic inclusions of mutant SOD1 were immune-positive for two reliable stress granule markers G3BP1 [31, 32] and TIA1 in the G93A mutant SOD1 transgenic mouse spinal cord (Fig. 1a, Supplemental Fig. 1), fibroblast cells derived from human ALS patient (Fig. 1c, Supplemental Fig. 3), and cultured cells (Fig. 1d, Supplemental Figs. 4, 5). This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.