Yet, during tuberculosis, we observed the inverse phenomenon of increased infection rates and T cell activation in the absence of the receptor at the early day 14 time point after infection, and, even when bacterial growth rates diverged between WT and fcgrt−/− mice by day 28, similar levels of CD4+ T cell activation could be observed despite the lower antigenic burden in protected fcgrt−/− animals. Here, CD4 is linked to infection.