Most articles reported on a combination of the subdomains (n = 20), which mainly focused (n = 16) on the following subdomains: physiological (e.g. transferrin saturation, blood pressure, calcium, albumin, haemoglobin, HbA1C, LDL-cholesterol), disease burden (e.g. cardiovascular disease, diabetes mellitus, hypertension), morbidity (e.g. EQ5D, KDQOL-36) and mortality (e.g. SMRs). This evidence concerns the gene TF and hypertensive disorder.