These loci identified by these 18 SNPs consisted of several previously reported genes including FGF5, ATP2B1, MTHFR, CASZ1, CYP11B2, CYP17A1, ADRB1, and HECTD48, 9, 11, as well as seven new genes (L3MBTL4, KIRREL, C9orf98, GALNT18, LOC729251, NLRP1 and TCEANC) that may be associated with hypertension. The gene discussed is AK8; the disease is hypertensive disorder.