In addition, we identified three SNPs in two novel genes (LOC729251 and TCEANC) and seven SNPs in five previously reported genes (FGF5, ATP2B1, CYP17A1, MTHFR and CASZ1) nominally associated with hypertension (Pmeta < 0.05) (Table 1). The gene discussed is MTHFR; the disease is hypertensive disorder.