Among the 1362 genes, we speculated that LTBP1 might participate in the effect of L3MBTL4 on vascular remodeling and hypertension, as there are evidence that anomalous expression of LTBP1 is detected in thoracic aortic aneurysm, and may promote the development of arterial diseases15, 16, Therefore the protein coding gene LTBP1 (Gene ID 4052) was further focused (Fig. 4f). Here, L3MBTL4 is linked to thoracic aortic aneurysm.