To determine the expression and distribution of L3MBTL4 in hypertension, we performed q-PCR and Western blotting, and compared L3MBTL4 mRNA and protein expression from different tissues of SHRs, the most widely-used animal model for hypertension, and WKYs, a normotensive reference group. The gene discussed is L3MBTL4; the disease is hypertensive disorder.