EGF and cancer: SERS and fluorescent signals could be excited independently using different wavelengths of light for combined cancer cell recognition.141 Monoclonal antibodies have also been used to selectively target 40 nm AuNPs with squaraine dye reporter molecules to epidermal growth factor and p16/Ki-67 receptors to achieve selectivity to and recognition of cancer cells’ surface and nucleus.142 Therefore, SERS can be presented as a potential means of fast and accurate cancer diagnosis compared to time consuming immunocytochemistry methods.141,142