ADAMTS13 and Thrombocytopenia: Adamts13+/+ mice injected with both 13B4 and 14H7 and triggered with rVWF developed severe thrombocytopenia (223 ± 101 x 103 platelets/μL compared to 723 ± 99 x 103 platelets/μL before injection of the trigger, Fig 6A) in contrast to mice injected with the control mAb 20A10 (611 ± 99 x 103 platelets/μL compared to 760 ± 168 x 103 platelets/μL before injection of the trigger, Fig 6A).