Serum TNF-α levels were not different, but serum leptin levels were higher in HH-HF mice compared to CC (6.7-fold, p = 0.0043) and HH (3.8-fold, p = 0.0106), and showed a tendency to increase 1.7-fold (p = 0.1803) in HH-HF compared with CC-HF mice as shown in Fig 3G and 3H. This evidence concerns the gene LEP and hydrops fetalis.