The rise in the proinflammatory cytokines (e.g., interleukin- (IL-) 1, IL-6, tumor necrosis factor- (TNF-) α, C-reactive protein (CRP), transforming growth factor- (TGF-) β, and leptin) or the fall in anti-inflammatory cytokines (e.g., interleukin-1 receptor antagonist (IL-1Ra), IL-4, IL-10, IL-13, and adiponectin) is the essential step in glucotoxicity and lipotoxicity induced mitochondrial injury, oxidative stress, and beta cell apoptosis in T2DM [2–4]. Here, IL6 is linked to type 2 diabetes mellitus.