Serum tryptase was associated with prediabetes (OR: 1.53 (1.01–2.32, 95% CI), P = 0.044) before adjustment and (OR: 1.63 (1.02–2.61, 95% CI), P = 0.041) after adjustment by multivariable + IL-4, compared with NGG. Here, IL4 is linked to prediabetes syndrome.