After the univariate analysis, these factors were as follows: ECOG ≥ 2, B symptoms, bulky disease, high IPI score, anemia (hemoglobin < 8 g/dL), elevated LDH, involvement of ≥3 extranodal sites, increased creatinine (>2 mg/dL), hypoalbuminemia (<3 g/dL), elevated beta-2 microglobulin, presence of infectious complications, required hospitalization, febrile neutropenia, and incomplete cycles of treatment. The gene discussed is B2M; the disease is Decreased total neutrophil count.