This mutation was evaluated by BIC database, mutation taster site and HGMD database as a pathologic mutation Interestingly, in both patients with BRCA mutation, IHC results and tumor markers status (ER, HER-2 and CK5/6) were identical to other patients, e.g. positive for ER and negative for the two other markers. This evidence concerns the gene ERBB2 and neoplasm.