As an agonist, IMiDs bound to cereblon complex promote the binding of some proteins including transcription factors implicated in multiple myeloma (such as Ikaros and Aiolos) (Krönke et al. 2014; Lu et al. 2014; Gandhi et al. 2014) or myelodysplastic syndrome (such as casein kinase 1α) (Krönke et al. 2015), which otherwise could not bind to cereblon. This evidence concerns the gene IKZF3 and myelodysplastic syndrome.