As an agonist, IMiDs bound to cereblon complex promote the binding of some proteins including transcription factors implicated in multiple myeloma (such as Ikaros and Aiolos) (Krönke et al. 2014; Lu et al. 2014; Gandhi et al. 2014) or myelodysplastic syndrome (such as casein kinase 1α) (Krönke et al. 2015), which otherwise could not bind to cereblon. The gene discussed is CRBN; the disease is AL amyloidosis.