MMP14 proteolytic activity is involved in directly activating MMP2 (Sato et al., 1994), and indirectly activating MMP13 (Knauper et al., 2002) and MMP9 (Toth et al., 2003), leading to enhanced cellular invasiveness, especially in cancer metastasis (Seiki et al., 2003). This evidence concerns the gene MMP14 and cancer.