MMP14 and glioblastoma: For example, overexpressing transmembrane and cytoplasmic domain of MMP14 in a human adenocarcinoma cell line was shown to enhance glucose uptake (Sakamoto, Niiya & Seiki, 2011) and glucose-6-phosphate transporter (G6PT) gene expression is upregulated in MMP14 silenced human glioblastoma cells (Belkaid et al., 2007).