It is believed that IBD is mostly triggered and aggravated by TNF-α released from infiltrating immune cells (macrophages), followed by increased concentrations of the cytokines IL-6 and IL-1β [13] and possibly IL-12 (especially for CD) and IL-13 (especially UC) [14], and reduced concentration of the anti-inflammatory cytokines IL-10 and IL-4 [15]. The gene discussed is IL10; the disease is inflammatory bowel disease.