Langer [12] found significant positive association between fasting glucose >105 mg/dL (5.83 mmol/L) and maternal and perinatal complications such as fetal macrosomia, neonatal hypoglycemia, hypertensive syndromes, and cesarean delivery and concluded that fasting glucose levels above this value are indicative of need for insulin therapy. This evidence concerns the gene INS and Large for gestational age.