CRHR1 and irritable bowel syndrome: CRF1 mRNA and CRF2 mRNA levels in DP-IBS and NDP-IBS patients were significantly higher than those in the control group (CRF1: 0.070 ± 0.004, 0.054 ± 0.002, and 0.041 ± 0.008, resp., F = 12.047, P < 0.01; CRF2: 0.0031 ± 0.0005, 0.0027 ± 0.0004, and 0.0018 ± 0.004, resp., F = 83.726, P < 0.01).