IL-10 mRNA expressions in DP-IBS and NDP-IBS patients were significantly lower than those in the control group (0.0092 ± 0.0019, 0.0059 ± 0.0015, and 0.0052 ± 0.0014, resp., F = 58.249, P < 0.05). This evidence concerns the gene IL10 and irritable bowel syndrome.