Immunohistochemical expression of PODXL could be assessed in 50/96 (52 %) samples with normal esophageal squamous epithelium, 79/131 (60 %) samples with normal gastric columnar epithelium, 51/73 (70 %) samples with intestinal metaplasia (Barrett’s esophagus or gastric intestinal metaplasia), 170/174 (98 %) samples with primary tumors, and 76/81 (94 %) samples with lymph node metastases. This evidence concerns the gene PODXL and Barrett esophagus.