Expression of PODXL was significantly higher in intestinal metaplasia (Barrett’s esophagus or gastric intestinal metaplasia) compared to normal epithelium (p < 0.001) and PODXL expression was significantly higher in primary tumors and lymph node metastases compared to intestinal metaplasia (p < 0.001). Here, PODXL is linked to esophageal adenocarcinoma.