TBX21 and hematocrit: T-bet is a direct transcriptional regulator of Th1 cytokines [21], commonly prevalent in both thyroid and PBMC of HT patients [22], and previously related to high TPOAb titres [23], disruption of thyroxisomes [24, 25] and apoptosis of thyroid follicular cells during in vitro induction of destructive autoimmune thyroiditis [26].