HOMA-IR was not cross-sectionally or longitudinally associated with the resistin level in CHC patients, confirming that human resistin levels are not associated with glucose homeostasis but are associated with genetics (RETN SNPs)14, 15, hepatic fibrosis/necroinflammation (ferritin)22, immunity (WBC counts)23, and renal function (GFR)24, even with HCV infection. Here, RETN is linked to Hepatic fibrosis.