It is possible that increased DNAM-1 expression on WASp KO and WAS patient NK cells leads to better killing of tumor cells that express DNAM-1 ligands, which are members of the Nectin/Nectin like family of adhesion molecules43, such as B16 melanoma cells and RMA-S lymphoma cells. The gene discussed is WAS; the disease is Wiskott-Aldrich syndrome.