Surprisingly, and on the contrary to what occurs in the liver, where Hepc transcription significantly decreases (Table 1), the pattern and the density of brain Hepc + cells in Tfr2-KO IDD mice remains comparable to WT (Fig. 3B–D,F–H), confirming the result of WB analysis. The gene discussed is TFR2; the disease is intervertebral disk degenerative disorder.