The result showed that all the female PyMT/CINAP+/+ mice spontaneously developed breast tumours at 70 days of age, whereas the PyMT/CINAP+/− mice started developing tumours at 90 days and only 40% (2/5) of the mice generated tumours at 120 days (Supplementary Fig. 4d). The gene discussed is AK6; the disease is breast neoplasm.