In settings of both allergy and autoimmunity, attenuation of reactivity has been linked to downmodulatory cytokine production, in particular IL-10 responses.84, 86 Among the most remarkable studies has been that of a cohort of patients with multiple sclerosis in Argentina who unintentionally acquired gastrointestinal helminth infections, with subsequent increased TGF-β and IL-10 levels and higher Treg and Breg cell activity. The gene discussed is IL10; the disease is helminthiasis.