A recurrent finding in these studies has been that helminth antigens (eg, secreted products or egg extracts) block the Toll-like receptor–stimulated pathway that leads to IL-12 production and TH1 induction.69, 70, 71 In terms of in vivo immunoregulation, DCs pulsed with Hymenolepis diminuta antigens are able to downmodulate dinitrobenzene sulfonic acid colitis in recipient mice, and CD4+ T cells from those recipients can be further transferred to new hosts and protect against colitis, requiring IL-10 production for their effect.72 The gene discussed is CD4; the disease is colitis.