MCM4 and dysplasia: Pairwise mean comparisons found the percentages of MCM4 and MCM7 expression significantly increased from columnar cell metaplasia, Barrett's esophagus, low-grade dysplasia to high-grade dysplasia (P < .05), except for squamous mucosa versus columnar cell metaplasia and esophageal adenocarcinoma versus high-grade dysplasia (Table 1).