In the current study, we first examined the immunohistochemical expression of MCM4 and MCM7 in comparison to the conventional proliferation marker Ki-67 in esophageal adenocarcinoma, squamous cell carcinoma, and precancerous lesions to determine the predictive value of these biomarkers for the progression of esophageal diseases. Here, MCM4 is linked to esophageal adenocarcinoma.