For renal carcinoma, obesity is associated with more indolent molecular variants (for example, reduced fatty acid synthase, FASN, gene expression) [12], while in contrast, for ovarian cancer, elevated BMI is associated with good prognosis cancers (low-grade serous and endometrioid), but within this histological type subpopulation, there is a linear positive association between BMI and mortality, which is absent in high-grade serous ovarian cancers [45]. Here, FASN is linked to obesity due to melanocortin 4 receptor deficiency.