HMGB1 is required for post‐APAP injury inflammation and has been shown to be pivotal in the progression of APAP‐ALI, and hepatocyte‐specific HMGB1 deficiency improves survival.14 In a clinical setting, HMGB1 serves as a promising sensitive and specific biomarker of APAP‐ALI, outperforming alanine aminotransferase (ALT) as a marker of progression and as an indicator of outcome.2, 10 The initial APAP‐induced hepatocyte necrosis results in an initial release of all‐thiol HMGB1. Here, GPT is linked to acute respiratory distress syndrome.