TOM1 and deafness: An myosin VI mutation (3496C > T) that causes deafness in Pakistani families leads to a premature stop in the C-terminal cargo-binding tail domain (at R1166X) and loss of the WWY motif, the binding site for myosin VI adaptor proteins, including Dab2, LMTK2 and Tom1/L2 (see Figure 1A).