CBLB and Autoimmunity: As a result, CBLB‐deficient T cells proliferate and synthesize cytokines following stimulation with suboptimal concentration of anti‐TCR antibody or in the absence of CD28 costimulation, and in turn, CBLB‐deficient mice are prone to autoimmunity (Gronski et al, 2004; Chiang et al, 2007; Teh et al, 2010; Zhou et al, 2014).