AKT1 and breast cancer: Kalinski et al. have shown that subjecting patients affected by stage I/III BC (including 3 women TN) at different doses of MK-2206, an allosteric inhibitor of AKT, they experienced rash and pruritus G3, mucositis G2, fever G2 and hyperglycemia G2, leading to the trial suspension, despite two dose reductions [96].