We have searched trials using Medline (PUBMED), EMBASE and COCHRAINE database, the following search strategy (“TNBC” [MESH] AND (“PI3K” [tiab] OR “mTOR” [tiab]) AND (“ER” [tiab] OR “PgR” [tiab]) and free text terms as “PI3K” [tiab], “triple negative breast cancer” [tiab] and “mTOR” [tiab]. The gene discussed is MTOR; the disease is triple-negative breast carcinoma.