In MM, a deregulated miRNAs expression in tumor cells has been associated to disease progression, pathobiology and DR, through modulating the expression of target genes involved in several pathways, such as p53, IGF-1/IGF-1R, VEGF/VEGF-R, NF-κB, IL-6-STAT3, SOCS1 [67-71]. The gene discussed is STAT3; the disease is neoplasm.