CAFs, in turn, modify the BM stroma and influence chemotaxis, adhesion, proliferation, and apoptosis of MM cells through cell-to-cell contact involving β3, β7, VLA-4, VLA-5 and αVβ3 integrins expressed on MM cells and β3 and β7 integrins expressed on CAFs, and the secretion of TGF-β, HGF, IGF-1, IL-1, IL-6 and SDF-1α by both cell types [113]. Here, IGF1 is linked to Miyoshi myopathy.