Enforced expression of pre-miRs-15a and -16 inhibits MM-BM stromal cells adhesion and MM cell proliferation, by inhibiting AKT3, ribosomal-protein-S6, MAP-kinases, NF-κB-activator MAP3KIP3, as well as limiting angiogenesis by decreasing VEGF secretion [80]. The gene discussed is NFKB1; the disease is Miyoshi myopathy.