Indeed, blockade of the TGF-β pathway by a TβR-I/II inhibitor induces apoptosis of bortezomib-resistant CAFs, by inhibiting the Smad2/3 and autophagy signaling pathways, and overcomes bortezomib resistance of MM cells conferred by CAFs [117]. The gene discussed is TGFB1; the disease is Miyoshi myopathy.