As reported in the article entitled “Chromatin remodeling factor LSH drives cancer progression by suppressing the activity of fumarate hydratase,” which was recently published in Cancer Research, our group examined the physiological role of lymphocyte-specific helicase (LSH) in nasopharyngeal carcinoma (NPC) by focusing on cancer progression and the tricarboxylic acid cycle. This evidence concerns the gene HELLS and cancer.