The results showed that CCNB2 abnormally expression maybe associated with IMQ induced psoriasis-form pathological lesion, and Psori-CM01 could inhibit the expression of CCNB2 both in the epidermis in IMQ model in vivo, and in LPS induced HaCaT cell hyper-proliferation model in vitro. Here, CCNB2 is linked to psoriasis.