F2RL1 and hepatocellular carcinoma: This was concluded from the finding that F2RL1 knockdown in hepatic stellate LX-2 cells inhibited the growth-promoting effect of these cells in a HCC xenograft SCID mouse model, as demonstrated by significantly smaller volumes of the tumours established in mice by coinjection of Hep3B and LX-2 cells depleted of PAR2.