F2RL1 and hepatocellular carcinoma: In the setting of liver cancer, it could be demonstrated that PAR2 is expressed in HCC tissues, different HCC cell lines and primary HCC cultures established from surgically resected specimens of primary HCCs, where it stimulates liver carcinoma cell migration and invasion via different signalling pathways including [Ca2+]i mobilisation, Src, Met and p42/p44 MAPK [40, 41], and is involved in the regulation of CD47+ HCC stem cells (tumour-initiating cells, TIC) [42].