EDN1 and neoplasm: ET-1-induced tumor promoting activities is also devoted to control migration and invasion, as well as epithelial-to-mesenchymal transition (EMT) and metastatic growth, most likely as consequence of a precise control over multiple signals, ranging from β-catenin signaling, EMT-related factors, integrin signaling as well as gap junction intercellular communication disruption [2, 10].