EDNRA and thyroid gland disorder: Based on the expression profiles of the ET-1R, there are cancers that predominantly express ETAR, such as ovarian, breast, colon, renal, gastric, pancreatic thyroid, and nasopharyngeal cancers; cancers expressing ETBR, such as melanoma, glioblastoma and astrocytoma, and those cancers expressing both ETAR and ETBR, such as bladder, lung, vulvar cancers and Kaposi’s sarcoma [2, 6].