A plethora of studies in different human cancer highlighted the efficacy of targeting ETAR in vitro and in preclinical models, in which ETAR blockade with different ETAR-selective antagonists (atrasentan and zibotentan) results in antitumour activity, by concomitant growth inhibition and apoptosis induction, an effect that can be potentiated from combined treatment of chemotherapeutics or targeted therapy [2, 10]. The gene discussed is EDNRA; the disease is cancer.