Importantly, we also observed a difference in the proportion of immune cells present at different sites: all tumor types showed a higher ratio of FoxP3+ cells to CD8+ cells in the tumor center, which is coherent with reports showing that tumors can recruit regulatory T-cells as part of their immune escape mechanism, and that these are better adapted to the tumor microenvironment, as they for example are more resistant to reactive oxygen [34, 35]. The gene discussed is CD8A; the disease is neoplasm.