Recently, as mentioned before, Cassar et al. [67] found that PAI-1 was the only biomarker linked to insulin resistance in PCOS subject, with high accuracy to predict IR (>70 %), while other biomarkers investigated in the study (ghrelin, visfatin, leptin, C-protein) were more strongly correlated with BMI rather than PCOS status. The gene discussed is LEP; the disease is polycystic ovary syndrome.