In the scientific literature, we found a strong connection between adipocytokines (in particular adiponectin, visfatin, vaspin and apelin), copeptin, irisin, PAI-1 and zonulin with insulin resistance and PCOS physiopathology, while the role of other proteins (such as resistin, leptin, RBP4, kisspetin and ghrelin) is still controversial. The gene discussed is LEP; the disease is Insulin resistance.