Different findings were reported by Jeon et al. [51] and Yilmaz et al. [52], who observed that kisspeptin levels were significantly increased in normal weight and obese PCOS women compared with controls with positive correlation with androgenic profile but without significant association with insulin resistance, suggesting that kisspeptin can be used as a specific marker for hyperandrogenism in PCOS. This evidence concerns the gene KISS1 and polycystic ovary syndrome.