Consistent with these findings, encouraging efficacy was reported in a non-randomised phase II clinical study, in which the anti-EGFR complement-activating antibody cetuximab was administered in combination with a soluble β-1,3/1,6-glucan to patients with KRAS-mutant/EGFR signalling-resistant colorectal carcinomas [38]. Here, EGFR is linked to colorectal carcinoma.