HSPA2 and colorectal carcinoma: For cellular proliferation and cell viability assay, CRC cells were transfected with HSP70-2 shRNA3 and shRNA4 which resulted in significant reduction in cellular growth of COLO205 with HSP70-2 shRNA3 (50 %; p < 0.01) and with HSP70-2 shRNA4 (56 %; p < 0.005) as compared to control NC shRNA transfected cells (Fig. 4c).