On the basis of lymph node involvement in CRC specimens, HSP70-2 IRS was 57.89 ± 1.77 in patients with lymph node involvement and 53.14 ± 3.36 in patients without lymph node involvement, while with respect to the presence or absence of metastasis, HSP70-2 IRS was 56.59 ± 3.21 in metastatic specimens and 57.11 ± 1.83 in specimens with no metastasis. This evidence concerns the gene HSPA2 and colorectal carcinoma.