Only few CT antigens namely sperm associated antigen 9 (SPAG9) [13], OY-TES-1 [16], New York-Esophageal (NY-ESO-1) [17], melanoma-associated antigen 3 (MAGE-A3) [18] and testis specific protease (TSP50) [19] association have been reported in CRC. The gene discussed is PRSS50; the disease is colorectal carcinoma.