Our results indicated that 65 % of CRC patients revealed high HSP70-2 IRS (69.42 ± 1.02) as compared to 35 % with low HSP70-2 IRS (33.97 ± 1.09) which was significantly different was observed among the groups (p < 0.0001) as analyzed using Mann Whitney U-test, depicted in histograph (Fig. 3). The gene discussed is HSPA2; the disease is colorectal carcinoma.