CI, confidence interval; EAC, esophageal adenocarcinoma; EC, esophageal cancer; EMSA, electrophoretic mobility shift assay; ESCC, esophageal squamous cell carcinoma; GWAS, genome-wide association studies; HR, hazard ratio; MAF, minor allele frequency; OR, odds ratio; PCR, polymerase chain reaction; Ptrend, P value for trend; RFT2, human riboflavin transporter 2; SNPs, single nucleotide polymorphisms. The gene discussed is SLC52A3; the disease is esophageal adenocarcinoma.