Interestingly, IFN signaling has been shown to crosstalk with the SHH pathway, and cerebellar atrophy is also a hallmark of Type I Interferonopathies (Moisan et al., 2015; Sun et al., 2010; McGlasson et al., 2015; Crow and Manel, 2015). The gene discussed is SHH; the disease is Cerebellar atrophy.