This could be consistent with previous reports showing hyperactivation of mTOR signaling in the brains of individuals with DS and mouse models of trisomy 21 and consequent impairments in autophagy (Ahmed et al., 2013; Perluigi et al., 2015; Troca-Marín et al., 2014; Iyer et al., 2014). This evidence concerns the gene MTOR and Dravet syndrome.